0102030405
Hexapeptide-10 Visibly Diminish Expression Lines & Firm Skin
01
Product Description
1. MOA
Hexapeptide-10 is a synthetic neurocosmetic peptide specifically designed to target dynamic expression lines through a unique mechanism of action.
SNARE Complex Modulation:
The peptide acts by mimicking the N-terminal domain of SNAP-25 protein
Competitively inhibits the formation of the SNARE complex (Soluble NSF Attachment Protein Receptor)
Disrupts the vesicle docking process required for acetylcholine release at neuromuscular junctions
Neuromuscular Signal Reduction:
Decreases the release of acetylcholine, the primary neurotransmitter responsible for muscle contractions
Reduces the intensity and frequency of facial muscle contractions that lead to expression lines
Provides a muscle-relaxing effect similar to botulinum toxin but through a reversible, non-paralyzing mechanism
Preventive Action:
Helps prevent the formation of new expression lines by maintaining reduced muscle activity
Allows existing wrinkles to smooth out through natural skin regeneration processes
2. In Vitro Efficacy Data
In-vitro studies demonstrate its potent biological activity:
SNARE Complex Inhibition Assay: Shows 72% inhibition of SNARE complex formation at 100 μM concentration
Acetylcholine Release Measurement: 58% reduction in acetylcholine release from neuronal cell models
Cell Viability Assay: Maintains 95% cell viability at effective concentrations, confirming excellent safety profile
Receptor Binding Studies: Demonstrates specific binding to target proteins involved in vesicle fusion
3. Clinical Results
12-week clinical study with 45 female volunteers (ages 35-55) using a cream containing 5% Hexapeptide-10:
Expression Line Reduction:
41% reduction in forehead line depth
38% improvement in crow's feet appearance
35% decrease in glabellar line severity
Skin Quality Parameters:
28% improvement in skin elasticity
32% increase in skin firmness
25% enhancement in skin smoothness
Subject Self-Assessment:
87% reported visible reduction in expression lines
92% noted improved skin texture and smoothness
85% would continue using the product
Tolerance: Excellent tolerance with no adverse effects reported
Safety Profile
*Non-toxic and non-irritating
*Non-sensitizing (0/50 subjects in HRIPT)
*Suitable for all skin types including sensitive skin
*Non-sensitizing (0/50 subjects in HRIPT)
*Suitable for all skin types including sensitive skin
Formulation Compatibility
pH Range: 5.0-7.0 (optimal stability)
Temperature Stability: Stable up to 40°C for 3 months Synergistic Combinations: Works well with hyaluronic acid, other peptides, and antioxidants
Temperature Stability: Stable up to 40°C for 3 months Synergistic Combinations: Works well with hyaluronic acid, other peptides, and antioxidants
Recommended Partners
*Hyaluronic acid for hydration
*Matrix-building peptides for comprehensive anti-aging *Antioxidants for enhanced protection
*Matrix-building peptides for comprehensive anti-aging *Antioxidants for enhanced protection
01
Recommended Usage & Dosage
Recommended Usage: 4-8% in final formulation
Optimal Formulations:
Anti-wrinkle serums and concentrates
Expression line targeting creams
Eye contour treatments
Professional cosmetic treatments
Daily moisturizers with anti-aging benefits
01
Targeted Action
Specifically designed to address dynamic expression lines at their neurological source
01
Proven Efficacy
Clinically demonstrated to reduce expression lines by up to 41%
03
Safe Alternative
Provides botulinum toxin-like effects through a safe, reversible mechanism
03
Multi-Zone Application
Effective on forehead, crow's feet, and glabellar lines
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available