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Pure Acetyl Hexapeptide-1 Hair Repair & Protection

Products Name Acetyl Hexapeptide-1
CAS No 448944-47-6
INCI Name Acetyl Hexapeptide-1
Specification ≥98% (HPLC)
Molecular Weight 687.8 g/mol
Chemical Formula C₃₂H₅₃N₉O₈
Appearance White to off-white lyophilized powder
Solubility Soluble in water

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    Product Description

    1. Mechanism of Action (MOA)
    Acetyl Hexapeptide-1 is a biomimetic peptide specifically designed to target hair shaft integrity and follicle health through multiple pathways:

    Hair Keratin Protection & Repair
    Mimics natural hair keratin sequences
    Penetrates hair shaft to fill surface defects
    Forms protective film on hair cuticle
    Follicle Activation Pathway
    Modulates Wnt/β-catenin signaling
    Promotes transition from telogen to anagen phase
    Extends growth phase duration

    Structural Reinforcement
    Enhances disulfide bond stability
    Improcomes hair fiber elasticity
    Reduces protein loss during washing

    2. In Vitro Efficacy Data
    Hair Fiber Studies
    67% reduction in combing force vs. untreated hair
    89% decrease in surface roughness (AFM analysis)
    45% improvement in hair tensile strength

    Follicle Cell Culture
    156% increase in keratinocyte proliferation
    78% upregulation in β-catenin signaling
    92% enhancement in VEGF production

    Barrier Function
    83% reduction in protein loss from damaged hair
    2.3-fold increase in moisture retention
    Significant improvement in cuticle integrity

    3. Clinical Results
    28-84 day clinical studies demonstrate:

    Hair Strength & Quality
    54% reduction in hair breakage (combing test)
    71% improvement in hair elasticity
    89% of subjects reported less frizz and better manageability

    Hair Growth Parameters
    23% increase in anagen/telogen ratio
    18% improvement in hair density
    31% reduction in daily hair shedding

    Overall Improvement
    94% satisfaction with hair strength
    87% reported shinier, healthier-looking hair
    Significant improvement in hair volume and body

    Safety & Compatibility

    Thickeners

    Safety Profile

    *Non-irritating to scalp and skin *Non-sensitizing at recommended concentrations *Suitable for color-treated and chemically processed hair
    Actives

    Formulation Compatibility

    *pH stability range: 3.5-8.0
    *Compatible with common hair care ingredients:
    Surfactants (SLS, SLES, betaines)
    Conditioning agents (silicones, cationic polymers)
    UV filters and heat protectants
    Natural oils and extracts
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    Recommended Usage & Formulations

    Optimal Concentration: 2-5%

    Preferred Formulations
    Shampoos and conditioners
    Hair serums and leave-in treatments
    Hair masks and deep conditioners
    Scalp tonics and growth treatments
    Styling products and heat protectants

    Application Frequency
    Daily use for maintenance
    Intensive treatment 2-3 times weekly for damaged hair

    Summary & Key Selling Points

    Applications1
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    Multi-Target Approach

    *Addresses both hair shaft quality and follicle health *Provides immediate and long-term benefits
    Applications3
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    Clinically Proven Efficacy

    *Significant reduction in hair breakage *Improved hair growth parameters *Enhanced overall hair quality
    Applications5
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    Superior Safety Profile

    *Gentle enough for daily use *Suitable for all hair types
    Applications5
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    Market Differentiation

    *Scientifically proven peptide technology *Dual action on hair fiber and follicle *Ideal for premium hair care positioning
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    Storage

    Store in a closed container at a dry place at room temperature.

    gmo1

    Animal Testing

    Not animal tested

    vegetarian1

    Vegan

    Does not contain animal-derived components

    gmo

    GMO

    No data available

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